Sampling schemes and drift can bias admixture proportions inferred by structure
نویسندگان
چکیده
منابع مشابه
Inferring admixture proportions from molecular data.
We derive here two new estimators of admixture proportions based on a coalescent approach that explicitly takes into account molecular information as well as gene frequencies. These estimators can be applied to any type of molecular data (such as DNA sequences, restriction fragment length polymorphisms [RFLPs], or microsatellite data) for which the extent of molecular diversity is related to co...
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The motions of a passive scalar â in a general high-frequency oscillating flow are studied. Our aim is threefold: (i) to obtain different classes of general solutions; (ii) to identify, classify, and develop related asymptotic procedures; and (iii) to study the notion of drift motion and the limits of its applicability. The used mathematical approach combines a version of the two-timing method,...
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Genetic admixture of distinct gene pools is the consequence of complex spatiotemporal processes that could have involved massive migration and local mating during the history of a species. However, current methods for estimating individual admixture proportions lack the incorporation of such a piece of information. Here, we extend Bayesian clustering algorithms by including global trend surface...
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Inference of population structure and individual ancestry is important both for population genetics and for association studies. With next generation sequencing technologies it is possible to obtain genetic data for all accessible genetic variations in the genome. Existing methods for admixture analysis rely on known genotypes. However, individual genotypes cannot be inferred from low-depth seq...
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For an admixed population, an important question is how much genetic contribution comes from each parental population. Several methods have been developed to estimate such admixture proportions, using data on genetic markers sampled from parental and admixed populations. In this study, I propose a likelihood method to estimate jointly the admixture proportions, the genetic drift that occurred t...
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ژورنال
عنوان ژورنال: Molecular Ecology Resources
سال: 2020
ISSN: 1755-098X,1755-0998
DOI: 10.1111/1755-0998.13234